The ACTC-DS repository is under review for potential modification in compliance with Administration directives.

Alzheimer’s Clinical Trials Consortium – Down Syndrome

Accelerating Alzheimer’s Research in Down Syndrome

We connect world-class clinical trials with the DS community to advance prevention and treatment of Alzheimer’s Disease.

Group photo of roughly 40 Alzheimer's Clinical Trials Consortium – Down Syndrome members wearing name badges at a conference.
A young woman and a young man, both with Down syndrome, smiling together outdoors.

Alzheimer’s disease in Down syndrome

People with Down syndrome are living healthier, longer and more independent lives than ever before. With this increased lifespan, we are finding that there is an increased risk for developing Alzheimer’s disease. There is an urgent need to find therapies that treat or prevent AD in people with Down syndrome. ACTC-DS aims to bring the latest and most innovative AD therapies to the DS population.

Make a Difference in Alzheimer’s Disease Research in Down Syndrome

Sites

23

Publications

+50

About

ACTC-DS infrastructure includes expertise in study design and conduct, and full clinical trial management capability through our coordinating center and network of trial sites.

Trials

We collaborate with leading investigators to develop and advance clinical trials focused on Alzheimer’s disease in Down syndrome, spanning early detection through later-stage interventions.

Sites

Our sites unite expert investigators across the US and Europe to advance Alzheimer’s disease research in the Down syndrome community.

A woman with Down syndrome and an older man smiling together outdoors, his arm around her shoulder.

TRC-DS reaches 450+ participants enrolled!

Explore ACTC-DS Studies and Clinical Trials

Discover ongoing research initiatives across our international network.

Learn About Our Trials

Research Starts With Partnership: Progress in Alzheimer’s disease research depends on individuals with Down syndrome, families, caregivers, and researchers working together.

A man with Down syndrome laughing joyfully alongside two friends, all leaning in close together.
A doctor talking warmly with a young man with Down syndrome during a medical visit.

For Researchers:

Join the ACTC-DS Research Network.

Collaborate with leading investigators advancing Alzheimer’s disease research in Down syndrome.