Marwan Noel Sabbagh, MD, board certified neurologist and geriatric neurologist, has dedicated his career to finding a cure for Alzheimer’s and other age-related neurodegenerative diseases.

Dr. Sabbagh is a leading investigator for many prominent national Alzheimer’s treatment trials. Dr. Sabbagh is on the editorial board for Journal of Alzheimer’s Disease and Alzheimer’s and Dementia TRCI. He is editor-in-chief of Neurology and Therapy. He has authored and co-authored over 450 medical and scientific articles on Alzheimer’s research.

Dr. Sabbagh is the author of The Alzheimer’s Answer: Reduce Your Risk and Keep Your Brain Healthy, with foreword by Justice Sandra Day O’Connor, and of The Alzheimer’s Prevention Cookbook: 100 Recipes to Boost Brain Health. He has edited Palliative Care for Advanced Alzheimer’s and Dementia: Guidelines and Standards for Evidence Based Care and Geriatric Neurology, published in 2014 and Fighting for my Life: living in the shadow of Alzheimer’s disease in 2019 and Strong Heart, Sharp Mind published in 2022.

Dr. Sabbagh earned his undergraduate degree from the University of California, Berkeley and his medical degree from the University of Arizona in Tucson. He received his residency training in neurology at Baylor College of Medicine, Houston, Texas, and completed his fellowship in geriatric neurology and dementia at the University of California, San Diego School of Medicine, where he served on the faculty as assistant professor.

Before joining the faculty of the Barrow Neurological Institute, he was the Camille and Larry Ruvo Endowed Chair for Brain Health, the Director of the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas and the founding Principal Investigator of the NIH funded Nevada Exploratory Alzheimer’s Disease Research Center. From 2000-2015, he was the director of the Banner Sun Health Research Institute in Sun City AZ. From 2015-2018, he was the Karsten Solheim Endowed Chair for Alzheimer’s research at the Barrow Neurological Institute. Presently, in addition to being vice chair, he also serves as Associate Program Director for Research for the Neurology Residency

Charles Bernick, MD, MPH, is Senior Director, Cognitive Disorders at the Cleveland Clinic Lou Ruvo Center for Brain Health. Dr. Bernick has been involved in the field of Alzheimer’s disease research and treatment for close to 40 years, beginning as the attending neurologist for the University of California, Davis Alzheimer’s Disease Diagnostic and Treatment Center. Dr. Bernick moved to Las Vegas in 1994 to join the University of Nevada School of Medicine and then joined the Cleveland Clinic Lou Ruvo Center for Brain Health in 2009. He has been involved in the clinical development of all the approved drugs for Alzheimer’s disease and has guided the Professional Fighters Brain Health study, a longitudinal cohort study of professional combatants aimed at understanding the effects of cumulative head trauma on brain structure and function.

He graduated summa cum laude from Rice University with a BA degree in history. He received his MD from University of Texas Southwestern, being elected to the medical honor society, alpha omega alpha. Dr. Bernick completed a neurology residency at the University of Miami, followed by a fellowship in neurology at the University of Arizona, and a Masters of Public Health at the University of Nevada, Las Vegas.

Anne-Sophie Rebillat is a geriatrician. Within the Jérôme Lejeune Institute in Paris, she runs a clinic specialized in the management of age-related diseases for patients with Down syndrome. Her research interest is mainly focused on comorbidities of cognitive functioning with aging in people with Down syndrome, e.g. Alzheimer’s disease and Obstructive Sleep Apnea.

Professor Kennelly is a consultant physician in geriatric and stroke medicine in Tallaght University Hospital (TUH) and Clinical Associate Professor of Medical Gerontology in Trinity College. He is Director of the Institute for Memory and Cognition, and the Cognitive Clinical Trials Unit in Tallaght University Hospital, Dublin. He is clinical director of the National Intellectual Disability Memory Service in TUH. He is lead-PI and chair of Dementia Research Network Ireland (DRNI), and co-lead investigator on Dementia Trials Ireland, a national clinical trials network. A fellow of the Royal College of Physicians in London & Ireland, he has extensively published in his main research areas of ageing, brain health and dementia. He has served as chief and principal investigator on several international clinical trials in early-stage Alzheimer’s disease. He is principle investigator and lead-clinical advisor on several industry collaborations investigating novel applications of digital gait and speech biomarkers in detection of cognitive decline. He is a member of the clinical and research advisory panel for the Alzheimer’s Society Ireland and a principal investigator in the Trinity College Institute of Neuroscience. He is a faculty member for the Global Brain Health Institute in Trinity College Dublin.

Dr. Real de Asúa MD, PhD (center PI) is an internist and clinical researcher with a special focus on caring for adults with Down syndrome (DS). In his clinical role as an attending physician at the Adult Down Syndrome outpatient of the Department of Internal Medicine, Hospital Universitario de La Princesa, in Madrid, Spain, he has focused on several areas of healthcare in this population, including cardiovascular health of adults with DS, overall- and COVID-19 related mortality risk factors in adults with DS and Alzheimer’s disease in this population.

The Adult Down Syndrome outpatient unit at the Department of Internal Medicine of the Hospital Universitario de La Princesa (Madrid) is the biggest outpatient clinic of its kind in the Madrid region. It provides care to over 1600 adults with DS, with close to 1000 visits per year. Since 2018, the Adult Down Syndrome unit is an active member of three international research networks: the DEGESCO consortium (Dementia Genetics Spanish Consortium, within the CIBERNED), the Trisomy 21 Research Society (T21RS) and the Reina Sofía Centre/CIEN Foundation (Neurological Disease Research Center). The site has access to a 3T MRI, EEG devices, and has a solid clinical trial unit.

Dr. Shrestha completed his general psychiatry residency at MetroHealth Medical Center in Cleveland, OH, and Behavioral Neurology and Neuropsychiatry fellowship at University Hospitals Cleveland Medical Center. He specializes in neuropsychiatric disorders, with a particular focus on diagnosis and management of dementia and associated disorders.

Dr. Shrestha has extensive experience in managing memory disorders such as Alzheimer’s disease and related disorders, as well as aging in Down syndrome. He is the principal investigator at Case Western Reserve University for Alzheimer’s Clinical Trials Consortium (ACTC). He conducts clinical research studies focusing on longitudinal observation of people with cognitive concerns, including Down syndrome, and clinical trials for prevention and treatment of Alzheimer’s disease.