Dr. Zaman is a consultant psychiatrist working with adults with intellectual disability in Cambridgeshire, a neuroscientist, and an associate lecturer at the University of Cambridge. He is part of the Cambridge Intellectual Disability Research Group at the Department of Psychiatry. He undertook higher training in medicine and psychiatry and was awarded a PhD in molecular neurobiology. He was a post-doctoral Wellcome Trust International Travelling Fellow at the Cold Spring Harbor Laboratory, New York. His research work focuses on the role of amyloid, tau, inflammation, and mitochondrial dysfunction in the genesis of cognitive impairment and dementia in people with Down Syndrome. He is part of the ABC-DS (Alzheimer’s disease Biomarker Consortium-Down Syndrome), which aims to understand the natural history of dementia in Down syndrome with the aim of designing clinical trials for preventive treatment. He is interested in understanding the neuronal mechanisms that underlie deficits in learning and memory in people with intellectual disabilities and exploring ways of ameliorating or treating these.

For the past 25 years, Dr. Espinosa has investigated novel mechanisms of gene expression control and molecular signaling in human health and disease, making significant contributions to the fields of parasitology, cancer biology, hypoxic signaling, and most recently, trisomy 21. In 2013, he received pilot funding from the Crnic Institute to apply his expertise in functional genomics to the study of Down syndrome. These activities led to the discovery that interferon signaling is consistently activated in multiple cell types with trisomy 21. Follow up studies demonstrated changes in the proteome, metabolome and immune cell repertoire indicative of interferon hyperactivity and increased JAK/STAT signaling in living individuals with Down syndrome. Altogether, these results support the hypothesis that interferon hyperactivity drives many of the developmental and clinical hallmarks of Down syndrome. Furthermore, Dr. Espinosa’s team recently reported the therapeutic benefits of JAK inhibition for autoimmune skin disease in Down syndrome, leading to the recent approval and funding through the INCLUDE Project of the first clinical trial for JAK inhibition in Down syndrome. Given the established role of neuroinflammation in Alzheimer’s disease, including demonstrated roles for interferon signaling in Alzheimer’s disease progression in animal models, this work could be of key relevance to the ACTC-DS mission.

At the Crnic Institute, Dr. Espinosa leads a dynamic and multidisciplinary research portfolio involving over 50 research teams across 25 departments at the University of Colorado. In 2016, Dr. Espinosa launched the Crnic Institute’s Human Trisome Project (HTP, www.trisome.org), a deep pan-omics cohort study of people with Down syndrome. The HTP was envisioned as a discovery accelerator for the field, pairing the generation of pan-omics datasets with deep clinical phenotyping on 1000+ individuals with trisomy 21, and making the data publicly accessible via a user-friendly online platform. In just three years, the HTP biobank has samples from >1500 participants, generated diverse multi-omics datasets, and created the first-ever online platform to explore the impact of trisomy 21 on these multidimensional datasets, called the TrisomExplorer: www.trisome.org/explorer. This project will be a great resource for the ACTC-DS both in terms of recruitment and multi-omics characterization.

Dr. Newhouse is the Director of the Center for Cognitive Medicine in the Department of Psychiatry at Vanderbilt University Medical Center that focuses on studies of the cognitive basis of neuropsychiatric disease.

Dr. Newhouse’s research has focused on central cholinergic mechanisms in Alzheimer’s disease and the role of cholinergic receptor systems in normal and disordered cognitive functioning in humans. He has also emphasized the development of novel cholinergic agents for clinical use in cognitive disorders. A second major focus includes studying the interaction of estrogen and related molecules on central cholinergic systems in relation to cognitive and emotional aging through the use of novel pharmacologic-imaging methodologies. Current foci in his lab include the effects of nicotinic and muscarinic mechanisms on cognitive functioning in aging, MCI and Alzheimer’s disease, the effects of nicotinic stimulation in older adults with Down syndrome, the effects of menopause on cholinergic-mediated cognitive performance in older women, and the treatment of mild cognitive impairment (MCI) with nicotinic stimulation. He has funding from NIA, NIMH, and private foundations.

He is a diplomat of the American Board of Psychiatry and Neurology in both General Psychiatry and Geriatric Psychiatry and in 2002 was awarded the American Psychiatric Association Profiles in Courage award. Dr. Newhouse serves as a frequent consultant to pharmaceutical and biotechnology companies in the United States and abroad on central nervous system drug development, clinical trial design for dementia and depression, and clinical nicotinic pharmacology.

Dr. Burke has worked extensively with patients and families suffering with neurodegenerative disorders including Alzheimer’s disease in Down Syndromw. Her area of expertise includes the diagnosis and management of cognitive disorders and the treatment of challenging behavioral and psychiatric disturbances that result from neurological conditions.

In addition to her clinical work, Dr. Burke has led the development of comprehensive multispecialty clinical care models focused on improving the quality of care for individuals with cognitive impairment and improving the diagnosis and management of Alzheimer’s and related dementias in the community.

She is a well-respected researcher having led over 80 clinical trials of investigational pharmacotherapies, neuromodulation, environmental modifications, prevention methods, and novel neuroimaging techniques.

Dr. Christian’s research and mentoring activities focus on developing and translating novel neuroimaging methods and PET radiotracers for the study of human development and neurodegeneration. This involves using neuroimaging to investigate neurochemical changes in the brain and studying novel radioligands to characterize neurotransmitter-protein interactions and how they are influenced by development, genes, environment and aging. He is also the Co-director of the Brain Imaging Lab and Director of the PET Imaging Core for the UW Alzheimer’s Disease Research Center (ADRC). He is currently Co-PI of the Alzheimer’s Biomarker Consortium – Down Syndrome (ABC-DS) project, a multicenter study of the progression of Alzheimer’s disease related biomarkers in adults with Down syndrome.

Dr. Ances’ research focuses on developing novel neuroimaging biomarkers for neurodegenerative diseases- especially Alzheimer’s disease (AD). He concentrates on functional and structural magnetic resonance imaging and positron emission tomography methods to detect early changes in the brain due to AD, and has pioneered the use of advanced neuroimaging techniques (including ASL and BOLD resting state functional connectivity) to study neurodegenerative diseases. Dr. Ances has assisted collaborators in the United States and abroad in implementing advanced neuroimaging techniques.